The opinions of researchers on the need for supplementing with methyl donors to avoid depletion is mixed.
It is theoretically possible, however, there has been no evidence of depletion, or the increased homocysteine levels that would result.
Dr. Charles Brenner flat declares they are not needed based on current research.
Dr. Chris Masterjohn thinks it's possible and Dr. David Sinclair has sometimes said he's added TMG to his routine just to be safe, but often doesn't mention that and seems undecided.
We agree it may be a good idea, which is why we add 5-methyltetrahydrofolate (5-MTHF) in the biologically active form of QUATREFOLIC® to our Energizer.
We provide one bottle of the NAD+ Energizer, Defender and Activator to all clients who receive the NAD+ IV therapy at The Restoration Clinic.